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罗成
发布时间: 2023-08-09  浏览次数: 17

罗成简介

罗成,男,197210月,有机化学博士,获国家杰出青年基金资助,入选科技部创新领军人才和中组部“万人计划”领军人才,上海市优秀学科带头人。现任中国科学院上海药物研究所研究员,博士生导师,研究领域:药物设计和化学生物学。以通讯、共同通讯或第一作者身份发表论文240篇,H因子47论著被引用近10000次。申请专利52项(美国专利2项、PCT 10项),获得授权专利10项(五项成果已经完成转化);主持“863”课题、基金委重点、杰出青年基金等项目10余项。

 邮箱:cluo@simm.ac.cn

19909-19946月,福州大学,化学系,化学,学士; 

199410-19985月,福州抗生素集团有限公司质量检测部助理工程师

19989-20016月,复旦大学,化学系,物理化学,硕士; 

20019-20046月,中国科学院上海药物研究所,有机化学,博士; 

20047-20059月,中国科学院上海药物研究所助理研究员,药物设计

    20059-20083月,宾夕法尼亚大学 Wistar研究所Ronen Marmorstein Lab,博士后,表观遗传学和化学生物学

    20083-200810月,中国科学院上海药物研究所助理研究员,药物设计与化学生物学;

    200810-201210月,中国科学院上海药物研究所,副研究员,硕导,药物设计与化学生物学;

    201210-至今,中国科学院上海药物研究所研究员,药物设计与化学生物学。

【学术兼职及荣誉称号】

1. 全国卫生生产业企业管理协会精准医疗分子常务理事

2. 中国生物化学与分子生物学会酶学专业分会委员

3. 中国药学会智能药物委员会委员

4. Chinese Journal of Chemistry杂志编委

 【学术兼职及荣誉称号】

1. 2019年上海市优秀学术带头人

2. 2016年药明康德生命化学研究奖


【主持项目】

     1. 国家自然科学基金委项目:基于翻译后修饰的难靶蛋白质化学探针发现技术体系构建及化学干预(重大研究计划重点支持项目),2019/1-2022/12,320万; 

2. 国家杰出青年科学基金项目:药物化学,2017/1-2021/12,400万;

3. 科技部国家重点研发计划项目:人工智能预测蛋白质动力学新技术开发及其在新药研发中的应用,2022/11-2027/12000万;

4. 国家自然科学基金委项目:基于甲基化、磷酸化、SUMO化等蛋白质修饰的抗肿瘤新靶标鉴定、功能调控与化学干预,2023/1-2025/12,1000万;

5. 上海市科学技术委员会项目:抗肿瘤新靶标的创新药物发现与作用机制研究,2019/5-2022/440

【近期发表论文】

1. Mingyu Wang#,Rongkun Lin#,Jiacheng Li#,Yuying Suo#,Jing Gao,Liping Liu,Liyuan Zhou,Yicheng Ni,Ziqun Yang,Jie Zheng,Jin Lin,Hu Zhou*,Cheng Luo*,Hua Lin* ,Discovery of LLK822 : A Selective, Durable, and Small-Molecule Degrader of the CDK8-Cyclin C Complex,Journal of Medicinal Chemistry, 2023,66(7):4932-4951

2. Ping Guo#, Shijia Zu#, Shilong Han#, Wendan Yu, Guoqing Xue, Xiaona Lu, Hua Lin,Xinrui Zhao, Haibo Lu, Chunyu Hua , Xinyu Wan, Liyuan Ru , Ziyue Guo , Hanxiao Ge ,Kuan Lva, Guohui Zhang , Wuguo Deng* , Cheng Luo*, Wei Guo* ,BPTF inhibition antagonizes colorectal cancer progression by transcriptionally inactivating Cdc25A, Redox Biology ,2022,55:102418

 3. Diao Xiaotong#, Ye Fei#, Zhang Meina, Ren Xintong, Tian Xiaoxu, Lu Jingping, Sun Xiangnan, Hou Zeng, Chen Xiaoyu, Li Fengwei, Zhuang Jingjing, Ding Hong, Peng Chao, Rastinejad Fraydoon*, Luo Cheng*, Wu Dalei*. Identification of oleoylethanolamide as an endogenous ligand for HIF-3α. Nature Communications. 2022,13(1):2529

4. Huang Jing#, Wang Xiaobo#, Li Bing#, Shen Shiyu, Wang Ruina, Tao Hongru, Hu Junchi, Yu Jin, Jiang Hualiang, Chen Kaixian, Luo Cheng*, Dang Yongjun*, Zhang Yuanyuan*. L-5-hydroxytryptophan promotes antitumor immunity by inhibiting PD-L1 inducible expression. Journal of Immunotherapy of Cancer. 2022,10(6):e003957

 5. Liu Liping#, Zhu Rui#, Li Jiacheng#, Pei Yuan#, Wang Shuangshuang, Xu Pan, Wang Mingyu, Wen Yu, Zhang Hao, Du Daohai, Ding Hong, Jiang Hualiang, Chen Kaixian, Zhou Bing, Yu Lifang*, Luo Cheng*. Computational and Structure-Based Development of High Potent Cell-Active Covalent Inhibitor Targeting the Peptidyl-Prolyl Isomerase NIMA-Interacting-1 (Pin1).  Journal of Medicinal Chemistry.2022,65(3):2174-2190

 6. Liping Liao#, Wenzhen Dang#, Tingting Lin#, Jinghua Yu, Tonghai Liu, Wen Li, Senhao Xiao, Lei Feng, Jing Huang, Rong Fu, Jiacheng Li, Liping Liu, Mingchen Wang, Hongru Tao, Hualiang Jiang, Kaixian Chen, Xingxing Diao, Bing Zhou*, Xiaoyan Shen*, Cheng Luo*, A potent PGK1 antagonist reveals PGK1 regulates the production of IL-1b and IL-6. Acta Pharm Sin B. 2022,12(11):4180-4192

 7. Jianhua Mao#, Kongkai Zhu#, Zhangbiao Long#, Huimin Zhang#, Bing Xiao, Wenda Xi,Yun Wang, Jiansong Huang, Jingqiu Liu, Xiaofeng Shi, Hao Jiang, Tian Lu, Yi Wen, Naixia Zhang, Qian Meng, Hu Zhou, Zheng Ruan, Jin Wang, Cheng Luo*, Xiaodong Xi* , Targeting the RT loop of Src SH3 in Platelets Prevents Thrombosis without Compromising Hemostasis. Advanced Science,2022,2103228.

 8. Heng Xu#, Hongfang Zhao#, Chunyong Ding#, Defang Jiang, Zijie Zhao, Yang Li, Xiaoyu Ding, Jing Gao, Hu Zhou, Cheng Luo, Guoqiang Chen, Ao Zhang*, Ying Xu*, Hao Zhang*, Celastrol suppresses colorectal cancer via covalent targeting peroxiredoxin 1, Signal Transduct Target Ther,2023,8(1):51

 9. Zhang Huimin#, He Jixiao#, Hu Guang#, Zhu Fei, Jiang Hao, Gao Jing, Zhou Hu, Lin Hua, Wang Yingjuan, Chen Kaixian, Meng Fanwang, Hao Minghong, Zhao Kehao*,Luo Cheng*, Liang Zhongjie*. Dynamics of Post-Translational Modification Inspires Drug Design in the Kinase Family.  Journal  of Medicinal Chemistry. 2021,64(20):15111-15125

 10. Lu Tian#, Lu Haibo#, Duan Zhe#, Wang, Jun , Han JieXiao Senhao, Chen Huanhuan, Jiang Hao, Chen Yu, Yang Feng, Chen, Dongying, Lin Jin, Li Bo, Jiang  Hualiang, Chen Kaixian, ,Lu Wenchao*, Lin Hua*, Luo Cheng *. Discovery of high-affinity inhibitors of the bptf bromodomain. Journal of Medicinal Chemistry,2021,64(16):12075-12088

 11. Daohai Du#,Dandan Xu#,Licheng Zhu#,Giulia Stazi, Clemens Zwergel, Yanli Liu, Zhongyuan Luo, Yuanqing Li, Yuanyuan Zhang, Kongkai Zhu, Yiluan Ding, Jingqiu Liu, Shijie Fan, Kaiyan Zhao, Naixia Zhang, Xiangqian Kong, Hualiang Jiang, Kaixian Chen, Kehao Zhao, Sergio Valente,*Jinrong Min,*Wenhu Duan,*and Cheng Luo*. Structure-Guided Development of Small-Molecule PRC2 Inhibitors Targeting EZH2-EED Interaction. Journal of Medicinal Chemistry,2021,64(12):8194-8207

 12. Tian Lu#, Yong Li#, Wenchao Lu#, TWGM Spitters, Jun Wang, Simian Cai, Jing Gao,  Yanting Zhou, Zhe Duan, Huan Xiong, Qi Li, Hualiang Jiang, Kaixian Chen, Hu Zhou, Hua Lin, Huijin Feng, Bing Zhou*, Christopher L. Antos* Cheng Luo*.Discovery of a subtype-selective, covalent inhibitor against palmitoylation pocket of TEAD3, Acta Pharmaceutica Sinica B, 2021,11(10), 3206-3219

 13. Shijie Fan#, Liyan Yue#, Wei Wan#, Yuanyuan Zhang#, Bidong Zhang#, Chinatsu Otomo, Quanfu Li, Tingting Lin, Junchi Hu, Pan Xu, Mingrui Zhu, Hongru Tao, Zhifeng Chen, Lianchun Li, Hong Ding, Zhiyi Yao, Junyan Lu, Naixia Zhang, Minjia Tan, Kaixian Chen, Yuli Xie, Takanori Otomo , Bin Zhou*, Hualiang Jiang*, Yongjun Dang*and Cheng Luo*. Inhibition of autophagy by a small molecule through covalent modification of LC3. Angewant Chemie-International Edition, 2021,60(50), 26105-26114

 14. Youyi Zhang#, Fei Ye#, Tongtong Zhang#, Shiyun Lv, Liping Zhou, Fei Guo, Daohai Du, Cheng Luo*, Shujia Zhu* Structural basis of ketamine action on human NMDA receptors. Nature,2021,596(7871):301-305.

 




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